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  • Schluss mit Parkinson

    Schluss mit Parkinson

    Enttäuschendes Ergebnis

    Wir hatten jeden einzelnen unserer Freunde sehr herzlich eingeladen, uns im Kampf gegen Parkinson zu unterstützen. Unsere online Petition war gleich hier zu unterschreiben und so oft wie möglich zu teilen. Auf diese Weise hatten wir gehofft, gemeinsam mit unseren Partnerorganisationen weltweit eine Million Unterschriften zu sammeln. Weit gefehlt, es wurden nur etwas über 6.000 ( 200 davon aus Österreich).

    Mehr als 10 Millionen Menschen leben mit der Parkinson-Krankheit. Es ist die am schnellsten wachsende neurologische Erkrankung der Welt. Sie ist degenerativ. Sie wird sich garantiert verschlimmern. Es gibt mehr als vierzig mögliche Symptome und die meisten Menschen denken, dass es nur eine wackelige Hand ist. Tatsächlich ist es eine lebenslange Strafe, gefangen zu sein in einem Körper, der sich zunehmend weigert, Befehlen zu gehorchen. Ein Gefängnis der Langsamkeit und Starrheit, in dem der oder die Einzelne mit getrübtem Verstand und gedämpfter Stimme zurückgelassen wird; eingesperrt in seelischen und körperlichen Schmerzen, langsam und lautlos sterbend. Schluss damit. Wir haben es satt.

    Wir fordern Wohlbefinden, politische Einflussnahme und Forschung. Auch wir glauben, dass jede Person, die mit Morbus Parkinson lebt, Zugang zu grundlegenden Therapien und Ressourcen haben sollte. Wir glauben, dass wir zu lange zu leise waren. Wir müssen eine laute, unbequeme, allgegenwärtige Stimme werden, die eine Veränderung in der Wahrnehmung und Behandlung der Krankheit fordert. Wir glauben, dass Parkinson durch Prävention und Forschung beseitigt werden kann. Wir fordern, dass mehr Mittel und Aufmerksamkeit auf die Beendigung der Krankheit und die Beseitigung ihrer vom Menschen gemachten Auslöser gelegt werden.

    Warum interessiert unser Schicksal keinen Menschen? Ist denn Brustkrebs, AIDS oder Multiple Sklerose sexier als Parkinson? Das kann es doch nicht sein. Die Welt ignoriert 10 Millionen Erkrankte, aber wir werden nicht aufgeben.

    Wir sind überall auf der Welt.

  • Parkinsong Award 4|2020

    Morphometric MRI Profiles of Multiple System Atrophy Variants and Implications for Differential Diagnosis

    Florian Krismer, PhD, et al

    Manual width measurements of the middle cerebellar peduncle on MRI were shown to improve the accuracy of an imaging‐guided diagnosis of multiple system atrophy (MSA). Recently, automated volume segmentation algorithms were able to reliably differentiate patients with Parkinson’s disease (PD) and the parkinsonian variant of MSA. The objective of the current study was to integrate probabilistic information of the middle cerebellar peduncle into an existing MRI atlas for automated subcortical segmentation and to evaluate the diagnostic properties of the novel atlas for the differential diagnosis of MSA (parkinsonian and cerebellar variant) versus PD.
    Three Tesla MRI scans of 48 healthy individuals were used to establish an automated whole‐brain segmentation procedure that includes the volumes of the putamen, cerebellar gray and white matter, and the middle cerebellar peduncles. Classification accuracy of segmented volumes were tested in early‐stage MSA patients (18 MSA‐parkinsonism, 13 MSA‐cerebellar) and 19 PD patients using a C4.5 classifier.
    Putaminal and infratentorial atrophy were present in 77.8% and 61.1% of MSA‐parkinsonian patients, respectively. Four of 18 MSA‐parkinsonian patients (22.2%) had infratentorial atrophy without evidence of putaminal atrophy. Infratentorial atrophy was present in all MSA‐cerebellar patients, with concomitant putaminal atrophy in 46.2% of these cases. The diagnostic algorithm using putaminal and infratentorial volumetric information correctly classified all PD patients and 96.8% of MSA patients.
    The middle cerebellar peduncle was successfully integrated into a subcortical segmentation atlas, and its excellent diagnostic accuracy outperformed existing volumetric MRI processing strategies in differentiating MSA patients with variable atrophy patterns from PD patients.

  • Parkinsong Award 3|2020

    Nigral Iron Deposition in Common Tremor Disorders

    Nina Homayoon, MD, et al

    We investigated R2* relaxation rates as a marker of iron content in the substantia nigra in patients with common tremor disorders and explored their diagnostic properties.
    Mean nigral R2* rates were measured in 40 patients with tremor-dominant Parkinson’s disease (PD), 15 with tremor in dystonia, 25 with essential tremor, and 25 healthy controls.
    Tremor-dominant PD patients had significantly higher nigral R2* values (34.1  5.7) than those with tremor in dystonia (30.0  3.9), essential tremor (30.6  4.8), and controls (30.0  2.8). An R2* threshold of 31.15 separated tremor-dominant PD from controls with a sensitivity and specificity of 67.5% and 72%. The sensitivity and specificity for discrimination between PD and non-PD tremor patients was 67.5% and 60%.
    Iron content in the substantia nigra is significantly higher in tremor-dominant PD than in tremor in dystonia, essential tremor, and controls. Because of the considerable overlap, nigral R2* cannot be suggested as a useful diagnostic tool.

  • Parkinsong Award 2|2020

    Individual Cognitive Change After DBS-Surgery in Parkinson’s Disease Patients Using Reliable Change Index Methodology

    Thomas Foki, MD, et al

    Long-term therapy of Parkinson’s disease (PD) with levodopa (L-DOPA) is associated with a high risk of developing motor fluctuations and dyskinesia. Deep brain stimulation (DBS) in PD patients of the subthalamic nucleus can improve these motor complications. Although the positive effect on motor symptoms has been proven, postoperative cognitive decline has been documented. To tackle the impact of PD-DBS on cognition, 18 DBS patients were compared to 25 best medically treated Parkinson’s patients, 24 Mild Cognitive Impairment (MCI) patients and 12 healthy controls using the Neuropsychological Test Battery Vienna-long (NTBV-long) for cognitive outcome 12 months after first examination. Reliable change index methodology was used. Overall, there was cognitive change in individual patients, but the change was very heterogeneous with gains and losses. Further research is needed to identify the mechanisms that lead to improvement or deterioration of cognitive functions in individual cases.

  • Parkinsong Award 1|2020

    Early Distinction of Parkinson-Variant Multiple System Atrophy from Parkinson’s Disease

    Alessandra Fanciulli, MD PhD, et al

    Distinguishing the Parkinson variant of MSA (MSA-P) from Parkinson’s disease (PD) is often difficult at disease onset. This is a major drawback for counseling of patients and timely enrollment into disease-modifying clinical trials.
    Clinicopathological studies consistently report that postural instability and autonomic failure emerge earlier in MSA-P than in PD,2,3 but it remains to be determined how this information can be integrated into the diagnostic work-up of patients with early parkinsonism.
    Here, we aimed at (1) quantifying the diagnostic yield of early-onset postural instability as well as cardiovascular and urological autonomic failure in differentiating MSA-P from PD and (2) merging early MSA-P distinctive features into a MSA-P diagnostic probability score.
    For this purpose, we retrospectively studied 161 PD and 29 MSA-P patients, who had undergone tilt-table testing at early disease, defined as Hoehn & Yahr (H&Y) stage <3 and/or disease duration <2 years. In the absence of neuropathological confirmation, established PD4 and MSA-P5 criteria were applied at last available visit by senior investigators and served as the clinical diagnostic gold standard. The diagnosis was further supported by cerebral MRI volumetry6 in all MSA-P patients with available MRI (n = 21) and in those PD patients with a follow-up time < 24 months and disease duration <5 years (n = 19): patients with a mismatch between the final clinical and MRI diagnosis were excluded from further analysis (n = 4). Clinical features at early disease, associated with a diagnosis of MSA-P at last available visit, were investigated by means of χ2, parametric, and nonparametric tests, followed by binary logistic regression analysis. An MSA-P diagnostic probability score was generated on the basis of early MSA-P discriminant variables. The study protocol was approved by the local ethical committee and performed according to the Declaration of Helsinki. Because of the retrospective design, no written informed consent was due. Processing of data followed the current Austrian regulation for data protection. By taking into account all significantly different clinical demographic traits at early disease, logistic regression analysis showed the following features to be associated with a final diagnosis of MSA-P: (1) postural instability (H&Y stage ≥3) within 2 years from disease onset; (2) orthostatic hypotension7; (3) symptoms of overactive bladder (urge and/or urinary incontinence); and (4) urinary retention (i.e., postvoid residual urine volume > 100 mL).
    By assigning 1 point per above-mentioned feature, a cumulative score ≥ 2 (score range: 0-4) showed 78% sensitivity (95% confidence interval [CI]: 58-91), 86% specificity (95% CI: 80-91), 50% positive predictive value (95% CI: 39-61), and 96% negative predictive value (95% CI: 91-98) for a final diagnosis of MSA-P. The area under the receiver operating characteristic (ROC) curve was 0.884 (95% CI: 0.823-0.946).
    We conclude that postural instability and autonomic failure manifest in both PD and MSA-P, but their early development indicates MSA-P.
    The 4-points MSA-P diagnostic probability score shows a balanced sensitivity and specificity for early MSA-P and represents an easily accessible, cost- and time-effective tool for screening parkinsonian patients with low or absent MSA risk (0–1 point) from those with high MSA-risk (2–4 points). The latter may benefit from referral to specialized movement disorder centers and, ultimately, recruitment in ongoing neuroprotective studies.

  • PARKINSONG STORY

    32 pages reviews, photos, background and making of Parkinsong Duets and Parkinsong Award, with World Parkinson Day on April, 11.

    PARKINSONG STORY
    32 pages reviews, photos, background and making of Parkinsong Duets and Parkinsong Award, with World Parkinson Day on April, 11.

    The PARKINSONG STORY in print for € 5 only

    Thank you

    Marino Acapulco – drums, voc., synths, Alois Aigner – Graz event, Ray Andrews – vocals, Kurt Bauer – violin, Eros Bresolin – vocals, Reinhard „Bux“ Brunner – mix, label, Jacques Bush – voc., guit., synths, Kurt Christian – vocals, guitars, Brian Dakin – vocals, Alessandra Fanciulli – award, Thomas Foki – award, Willi Gerschlager – jury, Alana de la Hidalga – Spanish translation, Beate Hilker – distribution, Andy Hitchman – vocals, Nina Homayoon – award, Julia Jockelson – vocals, Albi Klinger – bass, background voc., Florian Krismer – award, David Künstner – bass, Christian Lagger – event, John Langford – vocals, guitars, Philipp Mahlknecht – award, Karl Maier – jury, Karl Miklin – drums, background voc., Martin Novak – event PR, Gerhard Paar – keys, background voc., Franz Pennauer – jury, Mario Pohn – guitars, background voc., Anni Polacsik – jury, Eli Pollard – Kyoto event, Angelika Pudmich – keyboards, Peter Purgar – photography, Peter Rosegger – event, Jürgen Rottensteiner – music PR, Gerhard Rucker – jury, Uli Sajko – vocals, Ronald Saurugg – jury, Mireille Schmitt – French translation, Johann Schwarzinger – vocals, guitars, Petra Schwingenschuh – jury, Gerd Sojka – drums, background voc., Gisi Steinert – vocals, Alexander Tschiggerl – mix, master, Flo Verant – bass, Jörg Veselka – vocals, guitars, Pete Wain – vocals, guitars, Norbert Wally – vocals, guitars, Connie Weixler – vocals, Ingrid Winkler – jury, Klaus Wohlgemuth – guit., voc.

  • Der Grazer

    Presentation in Graz

    Der Grazer 2019-06-16 754 Seite 24
    Der Grazer, 16.6.2019, Page 24

  • Contacts

    Press Kit

    Rottensteiner Promotions
    Jürgen Rottensteiner
    Lainzer Strasse 11/12
    1130 Wien
    Austria

    mail: juergen@rottensteiner-pr.at
    facebook: jurgen.rottensteiner
    web: www.rottensteiner-pr.at

    Producer

    parkinsong.org-logo-white

    Gerald Ganglbauer
    Gangan Verlag
    Jakobsweg 18
    8046 Stattegg-Ursprung
    Austria

    mobile: +43 680 3136961
    mail: office@pon.or.at
    web: www.parkinsong.org
    web: www.parkinsoline.at

    Label

    ATS-Logo-White-100x283px

    Reinhard Brunner
    ATS-Records

    Breitenau 7
    4591 Molln
    Austria

    phone: +43 7584 2454
    mobile: +43 676 6803882
    facsimile: +43 7584 2454 24
    mail: office@ats-records.com
    web: www.ats-records.com
    UID:  ATU22379708

    Master

    BBS-Logo-210x170px

    Alexander Tschiggerl
    Black Box Sound Tonstudio

    Amselweg 20
    8046 Stattegg
    Austria

    mobile. +43 664 4926677
    mail: office@blackboxsound.com
    web: www.blackboxsound.com

  • Carmen

    Parkinsong Duets Vol. 2, performed by Musicgarden
    (Kurt Strohmeier and Xenia)

    Music by Georges Bizet
    Adaptation by Kurt Strohmeier
    Lyrics by Xenia Strunz

    carmen-simple2

    Have you ever felt that your life
    Isn’t going into the direction you want

    And your dreams and all your beliefs
    They seem to fade away with time

    Let them show you what they can teach you
    Don’t waste your time with stupid things

    Be aware that this life might be short
    And maybe ends before you know

    [bridge]

    Then change … your way … and love … will stay

    [chorus]

    The only thing you need is trust
    And just a little bit of joy and lust

    If you not want to fade away
    Like washed out colors when they fade to grey

    Whenever you feel down then think about the luck you have
    And do not hesitate and thank for all the bliss

  • Paul and Michael

    Paulsimon-michaeljfox
    Michael J Fox performing a duet with Paul Simon © michaeljfox.org

    Apparently Michael J Fox performed a duet with the great Paul Simon, but unfortunately none of them responded to my enquiries. The only proof is in the picture above, found somewhere on the Fox Foundation’s website without the music. A pity, because I would have loved to listen to them singing together. Could it perhaps go on Volume 2 of Parkinsong Duets?